General Information

  • ID:  hor001444
  • Uniprot ID:  A2TLI1
  • Protein name:  Gonadotropin-inhibitory hormone
  • Gene name:  NA
  • Organism:  Taeniopygia guttata (Zebra finch) (Poephila guttata)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Taeniopygia (genus), Estrildinae (subfamily), Estrildidae (family), Passeroidea (superfamily), Passeriformes (order), Neognathae (infraclass), Aves (class), Coelurosauria, Theropoda, Saurischia, Dinosauria, Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SIKPFSNLPLRF
  • Length:  12
  • Propeptide:  EEKQRSLNFEEMEDWRSKDIIKMNPFAASKMPNSVANLPLRFGRNYPEERSIKPFSNLPLRFGRAFGENIRNHAPKVSHRLERSPLVKGSSQSLLNLPQRFGKSLPVNLPRDVEEFEPGI
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A2TLI1-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001444_AF2.pdbhor001444_ESM.pdb

Physical Information

Mass: 161507 Formula: C68H107N17O16
Absent amino acids: ACDEGHMQTVWY Common amino acids: FLPS
pI: 11.65 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 5
Hydrophobicity: 8.33 Boman Index: -1319
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 97.5
Instability Index: 4395.83 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  22045661
  • Title:  Identification, expression, and physiological functions of Siberian hamster gonadotropin-inhibitory